CorroChip Cover is an innovative embedded sensor system that detects early signs of corrosion in reinforced concrete. It identifies the penetration of chlorides and other corrosion-causing contaminants into the concrete and measures the depth of the carbonation front. CorroChip Cover is highly effective at detecting the root cause of deterioration and the processes that initiate it, providing accurate, real-time data to protect your assets and optimize structural maintenance, extendin, extending their lifespans.

Main features:
- Early detection
- Remote monitoring
- Guaranteed durability
- Actionable information
- Customizable alerts
- Management platform

Characterize NRF2 modulation across inflammatory processes. In vitro & in vivo LPS activation in cells and mice; cytokine profiling. Key biomarkers: caspase-1, IL-1β, IL-18; tissue-level NRF2 pharmacodynamics. Deliverables: integrated cytokine profiles, mechanistic links to NRF2 activity.

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Evaluate NRF2 contribution in translational neurodegenerative models. Alzheimer’s: APP/TAU ± NRF2 models; pathology, neuroinflammation, and behavior. Parkinson’s: MPTP and α-synuclein models; motor and nigrostriatal biomarkers. CNS-NRF2 panel: integration of oxidative stress and inflammasome markers.

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Translational in vivo efficacy integrating NRF2 pharmacodynamic biomarkers. Endpoints: NAS (steatosis, inflammation, ballooning), fibrosis, ALT/AST, lipids, hepatic NRF2 biomarkers. Animal models: STAM and choline-deficient variants (in collaboration with IIB “Sols-Morreale” CSIC-UAM). Imaging: MRI for non-invasive hepatic/adipose metabolism assessment.

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Functional proof-of-concept across human and rodent cell systems. Oxidative stress challenges (t-BHP/H₂O₂) in hepatocytes, SH-SY5Y neurons, retinal and cardiac cells. Readouts: viability, ROS, apoptosis via flow cytometry and confocal microscopy. Pharmacodynamics: NRF2-dependent genes and proteins (HMOX1, NQO1).

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Early de-risking to flag promiscuous compounds and off-target liabilities. ADME/DMPK predictions (permeability, stability, PPB, clearance) AI-based toxicity alerts (hERG, CYP TDI, mitochondrial toxicity, etc.) Compound scoring and go/no-go recommendations.

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Demonstrate the robust, specific activation of NRF2 by candidate compounds. ARE-luciferase assays (EC50/IC50). KEAP1/NRF2 protein-protein interaction assays (FP/AlphaScreen). NRF2-dependent gene and protein expression profiling. Promoter occupancy confirmation (TransAM, ChIP-qPCR/ChIP-seq)

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A purse suturing device for a hollow viscus, such as the oesophagus or rectum, is a specialised surgical stapler used to prepare tissue for an anastomosis (the joining of two body structures).

This device is particularly useful in areas where hand-sewn suturing is difficult or impossible, such as during laparoscopic or pelvic surgery.Key components and features of the device include:Circular Stapler: Comprises a tubular stapler head, a handle with an actuator, and an anvil.

Dual-Position System:Pursing Position: The anvil is retracted from the stapler head, creating space for a suturing thread to be wound around the viscus.Stapling Position: The anvil moves close to the stapler head, compressing and folding the tissue layers together.Suturing Thread: Typically a plastic monofilament like polypropylene, which is wound around the tissue and tightened against the anvil's pole to create a pursed fold.

Pushing Stick: An optional tool used to fasten the thread tightly around the pole without needing to tie a knot.Staple Carrier: Includes a series of projections and recesses that hold the staples and provide space for the pushing stick to operate.This device improves surgical outcomes by providing a more secure and better-vascularised edge for subsequent procedures compared to traditional linear staplers, which can sometimes leave portions of the suture outside the target area.

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