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Accelerated Proof of Concept for MASH/NASH (12–16 weeks)

Accelerated Proof of Concept for MASH/NASH (12–16 weeks)

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Translational in vivo efficacy integrating NRF2 pharmacodynamic biomarkers. Endpoints: NAS (steatosis, inflammation, ballooning), fibrosis, ALT/AST, lipids, hepatic NRF2 biomarkers. Animal models: STAM and choline-deficient variants (in collaboration with IIB “Sols-Morreale” CSIC-UAM). Imaging: MRI for non-invasive hepatic/adipose metabolism assessment.

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