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Biomed services

Mechanism of Action and NRF2 Target Engagement
Demonstrate the robust, specific activation of NRF2 by candidate compounds. ARE-luciferase assays (EC50/IC50). KEAP1/NRF2 protein-protein interaction assays (FP/AlphaScreen). NRF2-dependent gene and protein expression profiling. Promoter occupancy confirmation (TransAM, ChIP-qPCR/ChIP-seq)

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0.00 € 0.0 EUR
In Silico Redox Selectivity and Preliminary Safety
Early de-risking to flag promiscuous compounds and off-target liabilities. ADME/DMPK predictions (permeability, stability, PPB, clearance) AI-based toxicity alerts (hERG, CYP TDI, mitochondrial toxicity, etc.) Compound scoring and go/no-go recommendations.

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0.00 € 0.0 EUR
Cytoprotection under Oxidative Stress (In Vitro PoC)
Functional proof-of-concept across human and rodent cell systems. Oxidative stress challenges (t-BHP/H₂O₂) in hepatocytes, SH-SY5Y neurons, retinal and cardiac cells. Readouts: viability, ROS, apoptosis via flow cytometry and confocal microscopy. Pharmacodynamics: NRF2-dependent genes and proteins (HMOX1, NQO1).

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0.00 € 0.0 EUR
Accelerated Proof of Concept for MASH/NASH (12–16 weeks)
Translational in vivo efficacy integrating NRF2 pharmacodynamic biomarkers. Endpoints: NAS (steatosis, inflammation, ballooning), fibrosis, ALT/AST, lipids, hepatic NRF2 biomarkers. Animal models: STAM and choline-deficient variants (in collaboration with IIB “Sols-Morreale” CSIC-UAM). Imaging: MRI for non-invasive hepatic/adipose metabolism assessment.

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0.00 € 0.0 EUR
Proof of Concept in Neurodegeneration (Alzheimer’s & Parkinson’s)
Evaluate NRF2 contribution in translational neurodegenerative models. Alzheimer’s: APP/TAU ± NRF2 models; pathology, neuroinflammation, and behavior. Parkinson’s: MPTP and α-synuclein models; motor and nigrostriatal biomarkers. CNS-NRF2 panel: integration of oxidative stress and inflammasome markers.

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0.00 € 0.0 EUR
Systemic Inflammation and Inflammasome Analytics
Characterize NRF2 modulation across inflammatory processes. In vitro & in vivo LPS activation in cells and mice; cytokine profiling. Key biomarkers: caspase-1, IL-1β, IL-18; tissue-level NRF2 pharmacodynamics. Deliverables: integrated cytokine profiles, mechanistic links to NRF2 activity.

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0.00 € 0.0 EUR

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Frequently Asked Questions about Marketplace

Where can I find verified scientific technologies or sell my university's patents to global buyers?

KnowTransfer operates as a specialized Sci-Tech Marketplace that bridges the gap between labs and corporations:

  • Global Visibility: We list your technology in a global database accessed by specialized investors and industrial scouts.
  • Verified Portfolio: Every technology in our marketplace has undergone a preliminary valuation and technology Readiness Level (TRL) check.
  • Direct Connections: We facilitate direct communication between technology owners and potential licensees or buyers.

KnowTransfer's advice: A patent is a dormant asset if it's not visible. Use a specialized marketplace to increase the chances of technology licensing.

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